This Week in Pediatrics
Q1 2026 recap: Top videos in pediatric care | Contemporary Pediatrics
The SMART trial serves as a pivotal study to bridge efficacy data from healthy infants, established in the CLEVER trial, to those with complex medical needs. Because clesrovimab is designed to target the viral F protein without interacting with the host, clinical protection is de...
Pediatrics - Medscape
Your one-stop resource for medical news, clinical reference, and education. Sign up for FREE ... The ‘Peanut Panic’ was a self-fulfilling prophecy. Dr Christopher Labos discusses the pediatric food allergy epidemic and how we’re finally reversing the trend.
Q1 2026 recap: 6 FDA approvals pediatricians need to know | Contemporary Pediatrics
Background: Based on the pivotal Phase 3 TRANSCEND trial of 142 patients including pediatric subjects, those treated with setmelanotide achieved a -18.4% placebo-adjusted reduction in body mass index at 52 weeks compared to a 2.6% increase in the placebo group. As the first and o...
Research of the Day
Probiotics for Infantile Colic: Randomized Controlled Trial of L. reuteri
This double-blind RCT enrolled 400 breastfed infants with colic to evaluate Lactobacillus reuteri supplementation. Infants receiving the probiotic showed significantly reduced crying time compared to placebo, with effects observed within 7 days of treatment initiation.
Key findings: (1) Mean crying time reduced by 51 minutes/day at 21 days; (2) 73% of treatment group had crying <3 hours/day vs 36% placebo; (3) No adverse events reported. Effect was specific to breastfed infants.
L. reuteri may be considered for breastfed infants with colic after excluding other causes. This is one of several evidence-based interventions alongside feeding adjustments, carrying techniques, and parental support.
Popular Beliefs
Wait 30 minutes after eating before swimming
What the evidence shows: There's no evidence that swimming after eating causes cramps or drowning. While digestion diverts some blood flow to the gut, it doesn't impair swimming ability in normal circumstances. Common-sense supervision is always important regardless of meal timing.
Warm milk helps children sleep
What the evidence shows: While milk contains tryptophan (a sleep-promoting amino acid), the amount is modest. Any sleep benefit likely comes from the comforting ritual and warmth rather than pharmacologic effect. A consistent bedtime routine matters more than any single component.
Cracking knuckles causes arthritis
What the evidence shows: Studies comparing habitual knuckle-crackers to non-crackers found no increased arthritis risk. The cracking sound is from gas bubble release in synovial fluid. The main consequence may be reduced grip strength and annoyed family members.
Behaviors
Early Pet Exposure and Immune Development: Birth Cohort Study
This birth cohort followed 1,200 children from birth to age 5, comparing immune development and allergy rates in homes with and without pets. Early pet exposure was associated with reduced allergy risk and altered gut microbiome.
Key findings: (1) 30% lower allergic sensitization with dog exposure in first year; (2) Cat exposure showed similar but smaller effects; (3) Microbiome diversity increased in pet-exposed children.
Reassure families that pet exposure during infancy may actually protect against allergies. For families without pets, don't specifically recommend getting one, but dispel the myth that pets must be removed to prevent allergies.
Genetics
CFTR Modulator Therapy in Young Children: Expansion to Additional Mutations
New clinical trial data supports expanding CFTR modulator therapy to children as young as 1 year with various CFTR mutations. Early treatment initiation shows benefits in lung function preservation and nutritional status, with excellent safety profile.
Key findings: (1) 85% of CF patients now eligible for modulator therapy; (2) Early treatment prevents rather than reverses lung damage; (3) Growth parameters improved in treated toddlers.
Refer CF patients promptly for genetic classification and modulator eligibility assessment. The treatment landscape has transformed—many children can now expect near-normal life expectancy with appropriate therapy.