This Week in Pediatrics
Q1 2026 recap: Top videos in pediatric care | Contemporary Pediatrics
The SMART trial serves as a pivotal study to bridge efficacy data from healthy infants, established in the CLEVER trial, to those with complex medical needs. Because clesrovimab is designed to target the viral F protein without interacting with the host, clinical protection is de...
Pediatrics - Medscape
Your one-stop resource for medical news, clinical reference, and education. Sign up for FREE ... The ‘Peanut Panic’ was a self-fulfilling prophecy. Dr Christopher Labos discusses the pediatric food allergy epidemic and how we’re finally reversing the trend.
Q2 2026 Preview: 6 FDA Decisions to Watch | HCPLive
Two-year DUPLEX data published in the New England Journal of Medicine showed significant proteinuria reduction, higher remission rates, and a lower rate of end-stage kidney disease compared to active control irbesartan.
Research of the Day
Early Antibiotic Exposure and Neurodevelopmental Outcomes: A Population-Based Cohort Study
This large population-based cohort study examined over 1.2 million children to investigate the association between antibiotic exposure in the first year of life and subsequent neurodevelopmental outcomes. The researchers found a modest but statistically significant association between early broad-spectrum antibiotic use and increased risk of ADHD and autism spectrum disorder diagnoses, though the absolute risk increase remained small.
Key findings include: (1) Children exposed to antibiotics in the first year had a 12% increased relative risk of ADHD diagnosis; (2) The association was stronger with repeated courses of broad-spectrum antibiotics; (3) The effect persisted after adjusting for maternal infections and other confounders.
While the study shows an association, causation is not established. The findings support judicious antibiotic use in infants—prescribing when clinically indicated, but avoiding unnecessary courses.
Popular Beliefs
Reading to babies is pointless—they don't understand
What the evidence shows: Research consistently demonstrates that reading to infants from birth supports language development, vocabulary acquisition, and later literacy skills. Even before understanding words, babies benefit from hearing language patterns, rhythm, and the bonding experience. The AAP recommends reading aloud beginning in infancy.
Sugar makes children hyperactive
What the evidence shows: Multiple double-blind, placebo-controlled studies have found no significant effect of sugar on behavior or cognitive performance in children, even in those reportedly 'sensitive' to sugar. The perceived hyperactivity is often due to the context (parties, holidays) or parental expectations. However, limiting added sugars remains important for dental health and nutrition.
Starve a fever, feed a cold
What the evidence shows: Neither fevers nor colds benefit from restricting food. Both conditions increase metabolic demands, and adequate nutrition supports immune function. Encourage normal eating as tolerated and emphasize hydration with any illness.
Behaviors
Physical Activity and Academic Achievement: School-Based Intervention Study
This cluster RCT examined whether increasing physical activity during the school day improved academic outcomes in 3,500 elementary students. Schools were randomized to add 30 minutes of daily activity or continue standard curriculum.
Key findings: (1) Intervention students showed 15% improvement in reading scores; (2) Math scores improved 8%; (3) On-task behavior increased and disruptive behavior decreased. Benefits were greatest for students with ADHD symptoms.
Advocate for physical activity in schools—it enhances rather than detracts from learning. Counsel families on the importance of daily active play for cognitive development, not just physical health.
Genetics
Gene Therapy for Phenylketonuria: Phase 2 Trial Results
Phase 2 trial results of a novel gene therapy for PKU show sustained reduction in phenylalanine levels, potentially eliminating the need for restrictive diet in some patients. Single-dose treatment showed effects lasting 2+ years in most participants.
Key findings: (1) 70% of participants achieved normal Phe levels without diet; (2) No serious adverse events; (3) Quality of life significantly improved with dietary liberalization.
Gene therapy is expanding beyond rare diseases to common metabolic conditions. For PKU families, inform them of emerging options while continuing to support dietary adherence.