This Week in Pediatrics
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FDA tracker: Novel approvals in pediatrics during 2026 | Contemporary Pediatrics
1. Copper histidinate (Zycubo; Sentynl Therapeutics Inc) Date: January 12, 2026 Indication: To manage Menkes disease in children. Background: Based on dedicated pediatric data from 2 open-label, single-arm clinical trials evaluating this ...
Can Energy Drinks Cause an 'Enlarged Heart'? Teen Dies After Drinking Too Many, Lawsuit Claims
The American Academy of Pediatrics advises against children and teens drinking anything with sugar and caffeine, and the current Dietary Guidelines for Americans recommend "significantly limiting sugary drinks and energy drinks" in teens and ...
Research of the Day
Early Antibiotic Exposure and Neurodevelopmental Outcomes: A Population-Based Cohort Study
This large population-based cohort study examined over 1.2 million children to investigate the association between antibiotic exposure in the first year of life and subsequent neurodevelopmental outcomes. The researchers found a modest but statistically significant association between early broad-spectrum antibiotic use and increased risk of ADHD and autism spectrum disorder diagnoses, though the absolute risk increase remained small.
Key findings include: (1) Children exposed to antibiotics in the first year had a 12% increased relative risk of ADHD diagnosis; (2) The association was stronger with repeated courses of broad-spectrum antibiotics; (3) The effect persisted after adjusting for maternal infections and other confounders.
While the study shows an association, causation is not established. The findings support judicious antibiotic use in infants—prescribing when clinically indicated, but avoiding unnecessary courses.
Popular Beliefs
Warm milk helps children sleep
What the evidence shows: While milk contains tryptophan (a sleep-promoting amino acid), the amount is modest. Any sleep benefit likely comes from the comforting ritual and warmth rather than pharmacologic effect. A consistent bedtime routine matters more than any single component.
Letting babies walk early causes bowlegs
What the evidence shows: There is no evidence that early walking causes bowlegs. Most infants have some degree of bowing that typically resolves by age 3-4. Pathologic bowing has other causes (Blount disease, rickets). Encourage normal motor development and monitor for asymmetric or progressive bowing.
Wait 30 minutes after eating before swimming
What the evidence shows: There's no evidence that swimming after eating causes cramps or drowning. While digestion diverts some blood flow to the gut, it doesn't impair swimming ability in normal circumstances. Common-sense supervision is always important regardless of meal timing.
Behaviors
Family Meal Frequency and Obesity Risk: Systematic Review and Meta-Analysis
This meta-analysis synthesized 45 studies examining the relationship between family meal frequency and childhood obesity. Children who shared regular family meals had significantly lower obesity risk and healthier eating patterns.
Key findings: (1) 3+ family meals/week associated with 12% lower overweight/obesity; (2) Higher fruit/vegetable intake and lower fast food consumption; (3) Protective effect independent of family structure or income.
Encourage family meals as part of healthy lifestyle counseling. Even a few shared meals per week make a difference. Focus on the ritual and connection, not just nutrition.
Genetics
CRISPR Gene Editing for Sickle Cell Disease: Long-Term Follow-Up
Long-term data from CRISPR-edited sickle cell patients shows durable remission of vaso-occlusive crises in 95% of treated patients at 4-year follow-up. The one-time treatment has transformed the disease trajectory for participants.
Key findings: (1) No vaso-occlusive crises in 95% of patients; (2) Hemoglobin levels maintained in normal range; (3) No off-target editing effects detected. Access and affordability remain challenges.
Curative therapy for sickle cell disease is now reality, though access barriers remain. Stay informed about treatment centers and insurance coverage in your area. Early referral for evaluation is appropriate.