This Week in Pediatrics
FDA news in pediatrics: June 2026 | Contemporary Pediatrics
On June 10, 2026, the FDA approved expanded indications for tocilizumab-bavi (Tofidence), adding severe or life-threatening CAR T-cell–induced cytokine release syndrome and hospitalized COVID-19 in patients aged 2 years and older, broadening ...
FDA updates in pediatric care: Q2 2026 recap | Contemporary Pediatrics
On April 22, 2026, the FDA approved dupilumab (Dupixent; Regeneron/Sanofi) for chronic spontaneous urticaria (CSU) in children aged 2 to 11 years who remain symptomatic despite H1-antihistamine therapy.
Top 5 pediatric health headlines you missed in January 2026 | Contemporary Pediatrics
Under the revised schedule, several vaccines—including those for hepatitis A, hepatitis B, respiratory syncytial virus, influenza, rotavirus, and meningococcal disease—are no longer routinely recommended for all children.
Research of the Day
Universal Depression Screening in Adolescents: Implementation and Outcomes
This pragmatic trial implemented universal depression screening using PHQ-9 Modified for Adolescents across 50 primary care practices. Universal screening identified 3x more cases of moderate-to-severe depression compared to targeted screening.
Key findings: (1) 18% of screened adolescents had positive screens requiring follow-up; (2) Early identification led to 40% increase in mental health referrals; (3) False positive rate acceptable at 12%.
Implement annual depression screening for all patients 12-21 years. Establish referral pathways and follow-up protocols. Address barriers to mental health access in your community.
Popular Beliefs
The flu shot can give you the flu
What the evidence shows: Flu vaccines contain inactivated virus or viral proteins that cannot cause influenza infection. Some people experience mild side effects (sore arm, low-grade fever) that mimic illness. It takes 2 weeks for protection to develop, so some may get infected before the vaccine works.
Cracking knuckles causes arthritis
What the evidence shows: Studies comparing habitual knuckle-crackers to non-crackers found no increased arthritis risk. The cracking sound is from gas bubble release in synovial fluid. The main consequence may be reduced grip strength and annoyed family members.
Remove ticks with a lit match or petroleum jelly
What the evidence shows: These methods can cause the tick to regurgitate into the wound, increasing disease transmission risk. Use fine-tipped tweezers to grasp the tick close to the skin and pull upward with steady pressure. Save the tick for identification if possible.
Behaviors
Physical Activity and Academic Achievement: School-Based Intervention Study
This cluster RCT examined whether increasing physical activity during the school day improved academic outcomes in 3,500 elementary students. Schools were randomized to add 30 minutes of daily activity or continue standard curriculum.
Key findings: (1) Intervention students showed 15% improvement in reading scores; (2) Math scores improved 8%; (3) On-task behavior increased and disruptive behavior decreased. Benefits were greatest for students with ADHD symptoms.
Advocate for physical activity in schools—it enhances rather than detracts from learning. Counsel families on the importance of daily active play for cognitive development, not just physical health.
Genetics
Gene Therapy for Phenylketonuria: Phase 2 Trial Results
Phase 2 trial results of a novel gene therapy for PKU show sustained reduction in phenylalanine levels, potentially eliminating the need for restrictive diet in some patients. Single-dose treatment showed effects lasting 2+ years in most participants.
Key findings: (1) 70% of participants achieved normal Phe levels without diet; (2) No serious adverse events; (3) Quality of life significantly improved with dietary liberalization.
Gene therapy is expanding beyond rare diseases to common metabolic conditions. For PKU families, inform them of emerging options while continuing to support dietary adherence.