This Week in Pediatrics
Contemporary Pediatrics – Clinical News & Pediatrician Practice Tips
Explore essential menstrual product options and education for adolescents, addressing safety, comfort, and personal preferences in menstrual health. ... Nihar R. Desai, MD, MPH; Martha Gulati, MD, MS, FACC, FAHA, MASPC, FESC, FSCCT (hon), FRCP Edin ... Adverse childhood experienc...
Executive Order Cuts Recommended Childhood Vaccines Down to 11: Report | PharmExec
President Trump signs an executive order shrinking the recommended childhood vaccine schedule from 18 diseases to 11, and calls for the MMR shot to be split into three separate injections.
What's new in pediatrics
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Research of the Day
Probiotics for Infantile Colic: Randomized Controlled Trial of L. reuteri
This double-blind RCT enrolled 400 breastfed infants with colic to evaluate Lactobacillus reuteri supplementation. Infants receiving the probiotic showed significantly reduced crying time compared to placebo, with effects observed within 7 days of treatment initiation.
Key findings: (1) Mean crying time reduced by 51 minutes/day at 21 days; (2) 73% of treatment group had crying <3 hours/day vs 36% placebo; (3) No adverse events reported. Effect was specific to breastfed infants.
L. reuteri may be considered for breastfed infants with colic after excluding other causes. This is one of several evidence-based interventions alongside feeding adjustments, carrying techniques, and parental support.
Popular Beliefs
Children outgrow ADHD
What the evidence shows: While symptoms often change with age, approximately 60% of children with ADHD continue to have symptoms into adulthood. Hyperactivity typically decreases, but inattention and impulsivity often persist. Ongoing monitoring and treatment adjustment is important across the lifespan.
Starve a fever, feed a cold
What the evidence shows: Neither fevers nor colds benefit from restricting food. Both conditions increase metabolic demands, and adequate nutrition supports immune function. Encourage normal eating as tolerated and emphasize hydration with any illness.
Letting babies walk early causes bowlegs
What the evidence shows: There is no evidence that early walking causes bowlegs. Most infants have some degree of bowing that typically resolves by age 3-4. Pathologic bowing has other causes (Blount disease, rickets). Encourage normal motor development and monitor for asymmetric or progressive bowing.
Behaviors
Physical Activity and Academic Achievement: School-Based Intervention Study
This cluster RCT examined whether increasing physical activity during the school day improved academic outcomes in 3,500 elementary students. Schools were randomized to add 30 minutes of daily activity or continue standard curriculum.
Key findings: (1) Intervention students showed 15% improvement in reading scores; (2) Math scores improved 8%; (3) On-task behavior increased and disruptive behavior decreased. Benefits were greatest for students with ADHD symptoms.
Advocate for physical activity in schools—it enhances rather than detracts from learning. Counsel families on the importance of daily active play for cognitive development, not just physical health.
Genetics
CRISPR Gene Editing for Sickle Cell Disease: Long-Term Follow-Up
Long-term data from CRISPR-edited sickle cell patients shows durable remission of vaso-occlusive crises in 95% of treated patients at 4-year follow-up. The one-time treatment has transformed the disease trajectory for participants.
Key findings: (1) No vaso-occlusive crises in 95% of patients; (2) Hemoglobin levels maintained in normal range; (3) No off-target editing effects detected. Access and affordability remain challenges.
Curative therapy for sickle cell disease is now reality, though access barriers remain. Stay informed about treatment centers and insurance coverage in your area. Early referral for evaluation is appropriate.