This Week in Pediatrics
Dolutegravir Antiretroviral Receives FDA Approval for Newborns With HIV
The antiretroviral dolutegravir (Tivicay PD, ViiV Healthcare) is now the first second-generation integrase strand transfer inhibitor (INSTI) available for use with other antiretroviral agents in newborns with HIV, following the FDA's August 26 approval of the drug for infant...
Professional Corner: Pediatricians Call for New Border Protections, AMA Awards $1 Million in Grants and More
The AHA opens its health tech competition, AMA awards $1 million in community grants, and pediatricians call for stronger protections for children at the US border.
Early Antiviral Therapy Linked to Reduced Risk for Influenza-Related Hospitalization in Children
Antiviral treatment started within 48 hours of symptom onset is linked to a reduced risk for hospitalization among pediatric patients with influenza.
Research of the Day
Adolescent Vaping Cessation: Randomized Trial of Behavioral Interventions
This RCT compared three vaping cessation approaches in 1,200 adolescents: text-based support, in-person counseling, and combined intervention. Combined approach showed highest quit rates at 6-month follow-up.
Key findings: (1) 28% quit rate with combined intervention vs 15% text-only; (2) Nicotine dependence level predicted quit success; (3) Most adolescents wanted to quit but lacked support resources.
Screen for vaping at every adolescent visit. Offer cessation resources proactively—most teens want to quit. Combine counseling with digital support for best outcomes.
Popular Beliefs
Reading to babies is pointless—they don't understand
What the evidence shows: Research consistently demonstrates that reading to infants from birth supports language development, vocabulary acquisition, and later literacy skills. Even before understanding words, babies benefit from hearing language patterns, rhythm, and the bonding experience. The AAP recommends reading aloud beginning in infancy.
Cold weather causes colds
What the evidence shows: Colds are caused by viruses, not cold temperatures. The association exists because people spend more time indoors in close proximity during winter, facilitating viral transmission. Additionally, dry indoor air may impair mucosal barriers. Hand hygiene and avoiding sick contacts are the real prevention strategies.
Letting babies walk early causes bowlegs
What the evidence shows: There is no evidence that early walking causes bowlegs. Most infants have some degree of bowing that typically resolves by age 3-4. Pathologic bowing has other causes (Blount disease, rickets). Encourage normal motor development and monitor for asymmetric or progressive bowing.
Behaviors
Physical Activity and Academic Achievement: School-Based Intervention Study
This cluster RCT examined whether increasing physical activity during the school day improved academic outcomes in 3,500 elementary students. Schools were randomized to add 30 minutes of daily activity or continue standard curriculum.
Key findings: (1) Intervention students showed 15% improvement in reading scores; (2) Math scores improved 8%; (3) On-task behavior increased and disruptive behavior decreased. Benefits were greatest for students with ADHD symptoms.
Advocate for physical activity in schools—it enhances rather than detracts from learning. Counsel families on the importance of daily active play for cognitive development, not just physical health.
Genetics
Gene Therapy for Congenital Hearing Loss: Breakthrough Trial
First successful gene therapy trial for DFNB9 deafness (otoferlin deficiency) shows restoration of hearing in children with previously profound hearing loss. Treated children gained ability to hear speech without cochlear implants.
Key findings: (1) 8 of 10 children gained functional hearing; (2) Benefit sustained at 18-month follow-up; (3) Earlier treatment showed better outcomes.
Genetic forms of deafness may become treatable. This changes the conversation with families about hearing loss prognosis. Genetic testing for hearing loss is increasingly important for treatment planning.